Hunger and Satiety Hormones High After Diet-and Exercise-Induced Weight Loss

by Natalie Digate Muth, MD, MPH, RDN, FAAP

Researchers are just beginning to understand why weight loss maintenance is so difficult. We know that at least part of the answer lies in metabolic changes that often accompany weight loss. For example, studies show that after diet-induced weight loss, the hunger hormone ghrelin increases, while satiety decreases amid declining levels of hormones such as peptide YY and glucagon-like peptide-1. After exercise-induced weight loss, hunger hormones also rise, but some studies suggest that satiety climbs as well.

A January study in the American Journal of Physiology-Endocrinology and Metabolism examined hormonal changes in response to weight loss induced through diet and exercise in a population of 35 adults with severe obesity. Researchers measured weight, cardiovascular fitness (VO2max), appetite feelings, and blood levels of the hormones insulin, ghrelin, glucagon-like peptide 1, peptide YY and cholecystokinin at baseline, 4 weeks, 1 year and 2 years.

The intervention included a 500-calorie-per-day dietary restriction with a healthy eating pattern high in fruits and vegetables; 50% of energy came from carbohydrates, 30% from fat and 20% from protein. Participants engaged in intensive activity during several 3-week stays at the research facility and were encouraged to engage in regular physical activity with an aim of at least 60 minutes of activity on most days and at least 2–3 resistance sessions per week when at home.

The researchers found that most participants could sustain weight loss until the 2-year mark, although hunger feelings and ghrelin levels stayed high after weight loss. Postmeal levels of satiety hormones were high as well, suggesting that people with severe obesity who lose weight with a diet-and-exercise intervention have to deal with increased hunger over the long term, even though they feel more full after eating.  IDEA Food and Nutrition Tips, Volume 7, Issue 3

Please review our business at:  Yelp     City Search    Angie’s List

Did you know you can work out and exercise with a trainer at your home, office, hotel room or pretty much anywhere in the world through live 2-way webcam using Skype?  Sign-up for a class with me today.

Click Here to sign-up for our e-mail list so can receive all of our articles & download your free copy of our Dietary Information e-book.

View our books on Amazon by Clicking Here. Learn how to get a free audio book with all of the key fitness and nutrition principles here.

Like us on Facebook/Connect with us on LinkedIn/Follow us on Twitter

Pinterest/Instagram/YouTube

(Hold down the Ctrl key & click the underlined words or logos)

Make sure to forward to friends and followers!

Book Personal Training from Destiny Management LLC in BellevueDestiny Management on Citysearch

Share on facebook
Facebook
Share on email
Email
Share on twitter
Twitter
Share on pinterest
Pinterest
Share on linkedin
LinkedIn

Leave a Reply